Áreas de Trabajo
BIOCHEMICAL AND MOLECULAR BIOLOGY STUDIES ON THE MICROBIAL SYNTHESIS OF SECONDARY METABOLITES.
Secondary metabolites are compounds with a wide range of chemical structures and biological activities synthesized by a few range of microorganisms usually at the late growth phase. Although involved in different functions (signalling differentiation, mediating ecological interactions and facilitating biochemical evolution in microorganisms), these metabolites are considered as secondary since are not essential for microbial growth. The remarkable diversity of biological functions and chemical structures characteristic of these metabolites reflects the random manner in which their biosynthesis has evolved and been exploited. It represents a form of inventive evolution in which metabolic opportunities that arose by chance were exploited and incorporated to various degrees into the phenotype of the species. Therefore it has been interesting for us to elucidate, at the biochemical and molecular biology levels, how these microorganisms are able to synthesize and regulate the production of these compounds. The impact of these studies can be situated at the general microbiology level, but also from the biotechnology standpoint since the resulting knowledge can be used to design rational genetic improvement and process optimization of secondary metabolites production.
PLANT-ASSOCIATED MICROBIAL SYSTEMS AS A SOURCE OF BIOLOGICALLY ACTIVE COMPOUNDS.
Plants and microorganisms synthesize most of the secondary metabolites with biological activity. Almost 50% of the biopharmaceutical have been obtained from plants. Plan-associated microorganisms (endophytic) such as bacteria or fungi produce many of these secondary metabolites. One endophytic fungi is Taxomyces andreanae, able to produce the anticancer drug, Taxol. Other endophytics have been shown to produce compounds with antibacterial, antiviral, antifungal and antimalarial activity. We are interested in the evaluation of medicinal plants as source of endophytic microorganisms as a way to look for new biologically active compounds.
Moreno-Mendieta S, Barrera-Rosales A, Mata-Espinosa D, Barrios-Payán J, Sánchez S, Hernández-Pando, S, Rodríguez-Sanoja R*.
Raw starch microparticles as BCG adjuvant: Their efficacy depends on the virulence of the infection strains
Vaccine En prensa IF: F.I. 3.33
Centeno-Leija A*, Tapia-Cabrera S, Guzmán-Trampe S, Esquivel B, Esturau-Escofet N, Tierrafría VH, Rodríguez-Sanoja R,
Zárate-Romero A, Stojanoff V, Rudiño-Piñera E, Sánchez S* and Serrano-Posada H*.
The structure of (E)-biformene synthase provides insights into the biosynthesis of bacterial bicyclic labdane-related diterpenoids
J Estruct Biol. doi: 10.1016/j.jsb.2019.04.010 En prensa IF: 3.433
Demain AL, Sánchez S.
Microbial synthesis of primary metabolites: Current trends and future prospects.
In: Mansi EL, Nielsen J, Mousdale D, Allman D, Carlson RP (Eds.).
Fermentation Microbiology and Biotechnology, 4th Edition. CRC Press; Taylor and Francis Group, Boca Raton. Chapter 4th, pp. 57-74. ISBN: ISBN 9781138581029.
Sánchez S*, Ruiz-Villafán B, Ceapă CD, Demain A.L.
Microbial synthesis of secondary metabolites and strain improvement. Current trends and future prospects.
In: Mansi EL, Nielsen J, Mousdale D, Allman D, Carlson RP (Eds.). Fermentation Microbiology and Biotechnology, 4th Edition. CRC Press; Taylor and Francis Group, Boca Raton. 2011, Chapter 5th, pp. 75-89. ISBN: ISBN 9781138581029.
Demain AL, Gómez-Ortiz B, Ruiz-Villafán B, Rodríguez-Sanoja R and Sánchez S*.
Recent findings of molecules with anti-infective activity: Screening of non-conventional
Curr Opin Pharm. En prensa. IF: 6.31
|Ajit Kumar Passari||Posdoctoral|
|Corina Diana Ceapa||Posdoctoral|
|Dulce María Ramírez Rendón||Doctorado|
|Karol Rodríguez Peña||Doctorado|
|Silvia Margarita Guzmán Trampe †||Doctorado|
|Brenda Gómez Ortiz||Maestría|
|Daniela Stefany Rodríguez Luna||Maestría|
|José Augusto Zelarayan Aguero||Maestría|
|Karen Villarreal Gómez||Maestría|
|Lenin Osel Pech Santiago||Maestría|
|María Paula Gómez Román||Maestría|
|Omar Jiménez Rodríguez||Maestría|
|Sarai Bata Ventura||Maestría|
|Diana Enríquez Vargas||Licenciatura|