Áreas de Trabajo
BIOCHEMICAL AND MOLECULAR BIOLOGY STUDIES ON THE MICROBIAL SYNTHESIS OF SECONDARY METABOLITES.
Secondary metabolites are compounds with a wide range of chemical structures and biological activities synthesized by a few range of microorganisms usually at the late growth phase. Although involved in different functions (signalling differentiation, mediating ecological interactions and facilitating biochemical evolution in microorganisms), these metabolites are considered as secondary since are not essential for microbial growth. The remarkable diversity of biological functions and chemical structures characteristic of these metabolites reflects the random manner in which their biosynthesis has evolved and been exploited. It represents a form of inventive evolution in which metabolic opportunities that arose by chance were exploited and incorporated to various degrees into the phenotype of the species. Therefore it has been interesting for us to elucidate, at the biochemical and molecular biology levels, how these microorganisms are able to synthesize and regulate the production of these compounds. The impact of these studies can be situated at the general microbiology level, but also from the biotechnology standpoint since the resulting knowledge can be used to design rational genetic improvement and process optimization of secondary metabolites production.
PLANT-ASSOCIATED MICROBIAL SYSTEMS AS A SOURCE OF BIOLOGICALLY ACTIVE COMPOUNDS.
Plants and microorganisms synthesize most of the secondary metabolites with biological activity. Almost 50% of the biopharmaceutical have been obtained from plants. Plan-associated microorganisms (endophytic) such as bacteria or fungi produce many of these secondary metabolites. One endophytic fungi is Taxomyces andreanae, able to produce the anticancer drug, Taxol. Other endophytics have been shown to produce compounds with antibacterial, antiviral, antifungal and antimalarial activity. We are interested in the evaluation of medicinal plants as source of endophytic microorganisms as a way to look for new biologically active compounds.
Demain, A.L. and Sánchez, S.
Enzymes of industrial interest.
Mexican Journal of Biotechnology 2(2):74-97
Romero Rodríguez, A., Rocha, D., Ruiz Villafán, B., Guzmán Trampe, S., Maldonado Carmona, N., Vázquez Hernández, M., Zelarayán, A., Rodríguez Sanoja, R., and Sánchez, S.
Carbon catabolite regulation in Streptomyces: new insights and lessons learned
World J Microbiol Biotechnol. 33:162-173 DOI 10.1007/s11274-017-2328-0
Vazquez-Hernandez, M., Ceapa, C.D., Rodríguez-Luna, S.D., Rodríguez-Sanoja R. and Sánchez, S.
Draft genome sequence of Streptomyces scabrisporus NF3, endophyte isolated from Amphipterigium adstringens.
Genome Announcements 5:e00267-17; doi:10.1128/genomeA.00267-17
Sanchez, S. and Demain, A.L.
The amazing world of antibiotics (Ed).
Biochemical Pharmacology. 133: 1-3. 2017. DOI:1016/j.bcp.2017.03.008
Guzmán-Trampe, S., Manzo-Ruiz, M., Ceapa C.D. and Sánchez, S.
Synthetic biology era: improving antibiotic´s world.
Biochemical Pharmacology. 133: 99-113. DOI: 10.1016/j.bcp.2017.01.015
|Corina Diana Ceapa||Posdoctoral|
|Silvia Margarita Guzmán Trampe||Doctorado|
|Brenda Gómez Ortiz||Maestría|
|Daniela Stefany Rodríguez Luna||Maestría|
|José Augusto Zelarayan Aguero||Maestría|
|Melissa Vázquez Hernández||Maestría|
|Nidia Maldonado Carmona||Maestría|
|Omar Jiménez Rodríguez||Maestría|
|Osiris Jair Patiño Chávez||Maestría|
|Sarai Bata Ventura||Maestría|
|Berenice Hernández Cordero||Licenciatura|