Sergio Sánchez Esquivel

Áreas de Trabajo

BIOCHEMICAL AND MOLECULAR BIOLOGY STUDIES ON THE MICROBIAL SYNTHESIS OF SECONDARY METABOLITES.

Secondary metabolites are compounds with a wide range of chemical structures and biological activities synthesized by a few range of microorganisms usually at the late growth phase. Although involved in different functions (signalling differentiation, mediating ecological interactions and facilitating biochemical evolution in microorganisms), these metabolites are considered as secondary since are not essential for microbial growth. The remarkable diversity of biological functions and chemical structures characteristic of these metabolites reflects the random manner in which their biosynthesis has evolved and been exploited. It represents a form of inventive evolution in which metabolic opportunities that arose by chance were exploited and incorporated to various degrees into the phenotype of the species. Therefore it has been interesting for us to elucidate, at the biochemical and molecular biology levels, how these microorganisms are able to synthesize and regulate the production of these compounds. The impact of these studies can be situated at the general microbiology level, but also from the biotechnology standpoint since the resulting knowledge can be used to design rational genetic improvement and process optimization of secondary metabolites production.

PLANT-ASSOCIATED MICROBIAL SYSTEMS AS A SOURCE OF BIOLOGICALLY ACTIVE COMPOUNDS.

Plants and microorganisms synthesize most of the secondary metabolites with biological activity. Almost 50% of the biopharmaceutical have been obtained from plants. Plan-associated microorganisms (endophytic) such as bacteria or fungi produce many of these secondary metabolites. One endophytic fungi is Taxomyces andreanae, able to produce the anticancer drug, Taxol. Other endophytics have been shown to produce compounds with antibacterial, antiviral, antifungal and antimalarial activity. We are interested in the evaluation of medicinal plants as source of endophytic microorganisms as a way to look for new biologically active compounds.

Publicaciones Recientes

Cruz-Bautista, R., Ruíz-Villafán, B., Romero-Rodríguez, A., Rodríguez-Sanoja, R., & Sánchez, S.
Trends in the two-component system’s role in the synthesis of antibiotics by Streptomyces.
Applied microbiology and biotechnology, DOI: 10.1007/s00253-023-12623-z. 2023

Rodríguez-Peña Karol; Gómez-Román María Paula; Macías-Rubalcava Martha Lidia; Rocha-Zavaleta Leticia; Rodríguez-Sanoja Romina; Sánchez Sergio
Bioinformatic comparison of three Embleya species and description of steffimycins production by Embleya sp. NF3.
Applied Microbiology and Biotechnology 106:3173-3190. 2022. doi. 10.1007/s00253-022-11915-0
2022

Romero-Rodríguez, Alba;, Martínez de la Peña, C; Troncoso-Cotal, S; Guzmán, C; Sánchez, Sergio
Emerging alternatives against Clostridioides difficile infection.
Anaerobe. 78:102638. doi: 10.1016/j.anaerobe.2022.102638.
2022

Ramírez-Rendón D, Kumar Passari A, Ruiz-Villafán B, Rodríguez-Sanoja R, Sánchez S, Demain AL.
Impact of novel microbial secondary metabolites on the pharma – industry.
Appl Microbiol Biotechnol.1855–1878. doi. 10.1007/s00253-022-11821-5
2022

Martin, Juan Francisco; Liras, Paloma; Sánchez, Sergio;
Modulation of gene expression in Actinobacteria by translational modification of transcriptional factors and secondary metabolite biosynthetic enzymes.
Frontiers in Microbiology doi: 10.3389/fmicb.2021.630694
2021

Integrantes de Grupo

Beatriz Ruiz Villafán

Estudiantes

Nombre	Nivel
Fernando Guzmán	Posdoctoral
Alma Reyna Campos	Doctorado
Berenice Hernandez Cordero	Doctorado
Carlos Adrian García Ausencio	Doctorado
Dulce Ramírez Rendón	Doctorado
Rodrigo Cruz	Doctorado
Alessandra Erosa Rivera	Maestría
Gladys Vega Sauceda	Maestría
Thalía Serrano Munguía	Maestría
Valerie Díaz Domínguez	Maestría
Yvette Ximena González López	Maestría
Jesus Emiliano Campoy Román	Licenciatura
Andrea Aguilar Cabrera	Licenciatura

Áreas de Trabajo (continuación)

Publicaciones Recientes (continuación)