Áreas de Trabajo
Nongenomic Effects of Steroid Hormones on Smooth Muscle.
The research work in this laboratory is in the effect and mechanism of action of steroid hormones. More specifically, we are interested in the membrane (non-genomics) mechanism by which the steroids are inducing rapid changes on the tissue excitability. Since 20 years ago, we have studied the relaxing effect and mechanism of action of 5alpha- and 5beta-reduced androgens and progestins on smooth muscle contractility, using as principal model the uterus of rats and humans. Additionally, we have reported that other smooth muscles such as: vascular, intestinal and airway are also relaxed by these steroids. In this context, our experiments have showed that the relaxing effect of steroids is non-genomically mediated, and it may be explained in terms of a blockade of voltage- and receptor-dependent calcium channels, a mechanism that restricts the availability of extracellular calcium in the contractile machinery.
Perusquía M, Greenway CD, Perkins LM, Stallone JN.
Systemic hypotensive effects of testosterone are androgen structure-specific and neuronal nitric oxide synthase-dependent.
American Journal of Physiology, Regulatory Integrative and Comparative Physiology 309: R189-R195 (ISSN: 0363-6135), FI: 3.88
Perusquía M, Flores-Soto E, Sommer B, Campuzano-González E, Martínez-Villa I, Martínez-Banderas AI, Montaño LM.
Testosterone induced relaxation involves L-type, store operated Ca2+ channels blockade and PGE2 in guinea pig airway smooth muscle.
Pflügers Archiv-European Journal of Physiology, (ISSN: 0031-6768), 467:767-777, FI: 4.86
Montaño LM, Espinoza J, Flores-Soto E, Chávez J, Perusquía M.
Androgens are bronchoactive drugs by relaxing airway smooth muscle and preventing bronchospasm.
Journal of Endocrinology, (ISSN 0022-0795), 22 (1): 1-13, FI: 4.05
F.N. Buijs, F. Cazarez, M.C. Basualdo, F.A.J. Scheer, M. Perusquía, D. Centurion, R.M.Buijs.
The suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response.
Neuroscience, (ISSN: 0306-4522), 266: 197-207. FI: 3.38
Espinoza J, Montaño LM, Perusquía M.
Nongenomic bronchodilating action elicited by dehydroepiandrosterone (DHEA) in a guinea pig asthma model.
Journal of Steroid Biochemistry and Molecular Biology, (ISSN: 0960-0760), 138: 174-182. FI: 3.98