Áreas de Trabajo
Nongenomic Effects of Steroid Hormones on Smooth Muscle.
The research work in this laboratory is in the effect and mechanism of action of steroid hormones. More specifically, we are interested in the membrane (non-genomics) mechanism by which the steroids are inducing rapid changes on the tissue excitability. Since 20 years ago, we have studied the relaxing effect and mechanism of action of 5alpha- and 5beta-reduced androgens and progestins on smooth muscle contractility, using as principal model the uterus of rats and humans. Additionally, we have reported that other smooth muscles such as: vascular, intestinal and airway are also relaxed by these steroids. In this context, our experiments have showed that the relaxing effect of steroids is non-genomically mediated, and it may be explained in terms of a blockade of voltage- and receptor-dependent calcium channels, a mechanism that restricts the availability of extracellular calcium in the contractile machinery.
Perusquia, M; Hanson, AE; Meza, CM; Kubli, C; Herrera, N; Stallone, JN.
Antihypertensive responses of vasoactive androgens in an in vivo experimental model of preeclampsia.
J Steroid Biochem Mol Biol. (2018), 178:65-72. FI. 4.095
Isidoro, L; Ferrer, M; Perusquia, M.
Vasoactive androgens: Vasorelaxing effects and their potential regulation of blood pressure.
Endocrin Res. (2018), 43(3):166-175. FI. 1.518
Flores-Soto, E., Reyes-García, J., Carbajal-García, A., Campuzano-González, E., Perusquía, M., Sommer, B., Montaño, L.M.
Sex steroids effects on guinea pig airway smooth muscle tone and intracellular Ca2+ basal levels
Mol Cell Endocrinol, 439:444-456 DOI: 10.1016/j.mce.2016.10.004
Perusquía, M., Herrera, N., Ferrer, M., Stallone, J.N.
Antihypertensive effects of androgens in conscious, spontaneously hypertensive rats
J Steroid Biochem Mol Biol, 167:106-114 DOI: 10.1016/j.jsbmb.2016.11.016
Romo-Nava, F., Buijs, F.N., Valdés-Tovar, M., Benítez-King, G., Basualdo, M., Perusquía, M., Heinze, G., Escobar, C., Buijs, R.M.
Olanzapine-induced early cardiovascular effects are mediated by the biological clock and prevented by melatonin
J Pineal Res, 62 (4), art. no. E12402 DOI: 10.1111/jpi.12402