Barrera-Chimal, J; Rocha, L; Amador-Martinez, I; Perez-Villalva, R; Gonzalez, R; Cortes-Gonzalez, C; Uribe, N; Ramirez, V; Berman, N; Gamba, G; Bobadilla, NA
Delayed spironolactone administration prevents the transition from acute kidney injury to chronic kidney disease through improving renal inflammation
Nephrology Dialysis Transplantation 34(5):794-801 F.I. 4.198
2019
García-Ortuño LE, Barrera-Chimal J, Pérez-Villalva R, Ortega-Trejo JA, Luna-Bolaños E, Lima-Posada I, Sánchez-Navarro A, Reyes-Castro L, Gamba G, Zambrano E, Bobadilla NA.
Resilience to acute kidney injury in offspring of maternal protein restriction
American Journal of Physiology-Renal Physiology 317(6):F1637-F1648 F.I. 3.323
2019
Sanchez-Navarro, A; Mejia-Vilet, JM; Villalva, RP; Carrillo-Perez, DL; Marquina-Castillo, B; Gamba, G; Bobadilla, NA
SerpinA3 in the Early Recognition of Acute Kidney Injury to Chronic Kidney Disease (CKD) transition in the rat and its Potentiality in the Recognition of Patients with CKD
Scientific Reports 9(1):10350 F.I. 4.011
2019
De los Heros P, Pacheco-Alvarez D & Gamba G.
Role of WNK kinases in the modulation of cell volume
Curr Topics Membr 81:207-235
2018
Argaiz ER, Chavez-Canales M, Ostrosky-Frid M, Rodríguez-Gama R, Vázquez N, Gonzalez-Rodriguez X, Garcia-Valdes J, Hadchouel J, Ellison D & Gamba G.
The Kidney Specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC
Am J Physiol Renal Physiol. 315:F734-F745
2018
Murillo-de-Ozores AR, Rodríguez-Gama A, Bazúa-Valenti S, Leyva-Ríos K, Vázquez N, Pacheco-Álvarez D, De La Rosa-Velázquez I, Wengie A, Stone KL, Loffing J, Lifton RP, Yang C-L, Ellison DH, Gamba G, & Castañeda-Bueno M.
C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity.
J Biol Chem, 293: 12209-12221, 2018-08-03
2018
Bazua-Valenti S, Rojas-Vega L, Castañeda-Bueno M, Barrera-Chimal J, Bautista R, Cervantes-Pérez LG, Vázquez N, Plata C, González-Mariscal L, Murillo-de-Ozores AR, Ellison DH, Riccardi D, Bobadilla NA & Gamba G.
The Calcium-sensing Receptor Increases Activity of the Renal NaCl Cotransporter Through the WNK4-SPAK Pathway.
J Am Soc Nephrol, 29:1838-1848
2018
Terker A, Castaneda-Bueno M, Ferdaus M, Cornelius R, Erspamer K, Su X-T, Miller L, McCormick J, Wang W-H, Gamba G, Yang C-L, and Ellison D.
With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo
Am J Physiol Renal Physiol. 315:F781-F790
2018
Moreno E, Gayosso J, Montejano JR, Almaguer G, Vázquez N, Cruz C, Mercado A, Bobadilla NA, Gamba G, Sierra A & Ramírez V.
Geraniin is a diuretic by inhibiting the Na+:K+:2Cl- cotransporter, NKCC2.
Am J Physiol Renal Physiol. 314:F240-F250
2018
Torre-Villalvazo I, Cervantes-Pérez LG, Noriega LG, Jimenez JV, Uribe N, Chávez-Canales M, Tovar-Palacio C, Marfil-Garza BA, Torres N, Bobadilla NA, Tovar AR & Gamba G.
Inactivation of SPAK kinase reduces body weight gain in mice fed a High-fat diet by improving energy expenditure and insulin sensitivity.
Am J Physiol Endocrinol Metabolism. 314:E53-E65
2018
Cervantes- Pérez LG, Castañeda-Bueno M, Jimenez V, Vázquez N, Rojas-Vega L, Alessi D, Bobadilla NA & Gamba G.
Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II.
Journal of Hypertension, 18:361-367
2018
Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough III O, Shibata S, Rojas-Vega L, Gamba G, Rinehart J, Lifton R.
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
Proc Natl Acad Sci USA. 114:E879-E886
2017
Barba-Navarro R, Tapia-Silva M, Garza-Garcia C, López-Giacoman S, Melgoza-Toral I, Vázquez-Rangel A, Bobadilla NA, Baranda F, Chawla LS, Gamba G & Madero M.
The Effect of Spironolactone on Acute Kidney Injury after Cardiac Surgery. A Randomized Placebo Controlled Trial.
Am J Kid Dis. 69:192-199
2017
Moreno E, Plata C, Rodríguez-Gama A, Argaiz ER, Vázquez, Leyva-Ríos K, Islas L, Cutler C, Pacheco-Alvarez D, Mercado A, Cariño R, Castañeda-Bueno M, & Gamba G.
European Eel NCCb is a Thiazide-resistant Na+:Cl- Cotransporter.
J Biol Chem. 291, 22472-22481
2016
Argaiz ER & Gamba G.
On the molecular mechanism of renal salt excretion modulation by extracellular potassium.
J Physiol. 594:6071-6072
2016
Mercado A, de los Heros P, Melo Z, Chavez-Canales M, Murillo A, Moreno E, Bazúa-Valenti S, Vázquez N, Hadhouel J & Gamba G.
With no lysine L-WNK1 isoforms are negative regulators of the K+:Cl- cotransporters.
Am J Physiol Cell Physiol. 311:C54-C66
2016
Bazúa-Valenti S, Castaneda-Bueno M & Gamba G.
Physiological Role of SLC12 Family Members in the Kidney.
Am J Physiol Renal Physiol. 311:F131-F144
2016
Gamba G.
The Evolving Field of Salt Transport Regulation in the Steve Hebert Lecture.
Am J Physiol Renal Physiol. 311:F68-F70
2016
Ellison DH, Terker AS, Gamba G.
Potassium and Its Discontents: New Insight, New Treatments.
J Am Soc Nephrol 27:981-989
2016
Hadchouel J, Ellison DH, Gamba G.
Regulation of Renal Electrolyte Transport by WNK and SPAK/OSR1 Kinases.
Annu Rev Physiol. 78:367-389
2016
Terker AS, Zhang C, Erspamer KJ, Gamba G, Yang C-L & Ellison DH.
Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis.
Kidney International. 89:127-134
2016
Rojas-Vega L & Gamba G
Hormonal regulation of the renal NaCl cotransporter.
Am J Physiol Renal Physiol. 310:F10-F14
2016
Rojas-Vega L, Jiménez AR, Bazúa-Valenti S, Arroyo-Garza I, Jiménez JV, Gómez-Ocádiz R, Carrillo-Pérez DL, Moreno E, Morales-Buenrostro LE, Alberú J, & Gamba G.
Increased phosphorylation of the renal Na+-Cl- cotransporter in kidney transplant recipient patients with hypertension: a prospective cohort
Am J Physiol Renal Physiol. 309:F836-F842
2015
Bazúa-Valenti S, Chávez-Canales M, Rojas-Vega L, Vázquez N, Rodriguez-Gama A, Melo Z, Plata C, Ellison DH, Hadchouel J & Gamba G.
The effect of WNK4 on the NaCl cotransporter is modulated by intracellular chloride.
J Am Soc Nephrol. 26:1781-1786
2015
Bazúa-Valenti S & Gamba G.
Revisiting the NaCl cotransporter regulation by the with no lysine kinases.
Am J Physiol Cell Physiol, 308:C779-C791
2015
Rojas-Vega L, Reyes-Castro LA, Ramirez V, Bautista R, Rafael C, Castañeda-Bueno M, Meade P, De los Heros P, Arroyo-Garza I, Bernard V, Binart N, Hadchouel J, Bobadilla NA, Zambrano E & Gamba G.
Ovarian Hormones and Prolactin Increase the Renal NaCl Cotransporter Phosphorylation.
Am J Physiol Renal Physiol, 308:F799-F808
2015
McCormick JA, Yang CL, Zhang C, Davidge B, Katharina B, Terker A, Yarborogh B, Meermeier N, Park H-J, McCully B, West M, Borschewski A, Himmikus N, Bleich M, Bachmann S, Mutig K, Argaiz E, Gamba G, Singer J, Ellison DH.
Dominant CUL3 mutations degrade KLHL3 to promote WNK signaling in hyperkalemic hypertension
J Clin Invest, 124:4723-4736
2014
Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G & Hadchouel J.
The WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the NaCl cotransporter via SPAK, an effect antagonized by WNK4
Hypertension, 64:1047-1053
2014
Lagnaz D, Arroyo JP, Chávez-Canales M, Vázquez N, Rizzo F, Spirlí A, Debonneville A, Staub O, Gamba G. WNK3 abrogates the Nedd4-2-mediated inhibition of the renal NaCl cotransporter.
Am J Physiol Renal Physiol, 307:F275-F286
2014
Castañeda-Bueno M, Cervantes-Perez L, Rojas-Vega L, Arroyo-Garza I, Vázquez N, Moreno E, & Gamba G. Modulation of NCC activity by low and high K+ intake: insight into the signaling pathways involved.
Am J Physiol Renal Physiol, 306:F1507-F1519
2014
Melo Z, Cruz-Rangel S, Bautista R, Vázquez N, Mount DB, Mercado A and Gamba G.
Molecular evidences for K-Cl cotransporters role in the kidney.
Am J Physiol Renal Physiol, 305:F1402-F1411
2013
Shibata S, Rinehart J, Zhang J, Moeckel G, Castañeda-Bueno M, Stiegler AL, Boggon TJ, Gamba G, and Lifton RP.
Mineralocorticoid receptor phosphorylation regulates ligand binding and receptor activation.
Cell Metabolism, 18:660-671
2013
Melo Z, de los Heros P, Cruz-Rangel S, Vazquez N, Bobadilla NA, Alessi DR, Morales-Pasantes H, Mercado A & Gamba G.
N-terminal serine dephosphorylation is required for full activation of KCC3 during cell swelling.
J Biol Chem, 288:31468-31476
2013
Arroyo JP, Kahle KT & Gamba G.
The SLC12 family of electroneutral cation-coupled chloride cotransporters.
Molec Asp Med, 34:288-298
2013
