Áreas de Trabajo
BIOCHEMICAL AND MOLECULAR BIOLOGY STUDIES ON THE MICROBIAL SYNTHESIS OF SECONDARY METABOLITES.
Secondary metabolites are compounds with a wide range of chemical structures and biological activities synthesized by a few range of microorganisms usually at the late growth phase. Although involved in different functions (signalling differentiation, mediating ecological interactions and facilitating biochemical evolution in microorganisms), these metabolites are considered as secondary since are not essential for microbial growth. The remarkable diversity of biological functions and chemical structures characteristic of these metabolites reflects the random manner in which their biosynthesis has evolved and been exploited. It represents a form of inventive evolution in which metabolic opportunities that arose by chance were exploited and incorporated to various degrees into the phenotype of the species. Therefore it has been interesting for us to elucidate, at the biochemical and molecular biology levels, how these microorganisms are able to synthesize and regulate the production of these compounds. The impact of these studies can be situated at the general microbiology level, but also from the biotechnology standpoint since the resulting knowledge can be used to design rational genetic improvement and process optimization of secondary metabolites production.
PLANT-ASSOCIATED MICROBIAL SYSTEMS AS A SOURCE OF BIOLOGICALLY ACTIVE COMPOUNDS.
Plants and microorganisms synthesize most of the secondary metabolites with biological activity. Almost 50% of the biopharmaceutical have been obtained from plants. Plan-associated microorganisms (endophytic) such as bacteria or fungi produce many of these secondary metabolites. One endophytic fungi is Taxomyces andreanae, able to produce the anticancer drug, Taxol. Other endophytics have been shown to produce compounds with antibacterial, antiviral, antifungal and antimalarial activity. We are interested in the evaluation of medicinal plants as source of endophytic microorganisms as a way to look for new biologically active compounds.
Guzmán-Trampe, S., Manzo-Ruiz, M., Ceapa C.D. and Sánchez, S.
Synthetic biology era: improving antibiotic´s world.
2017. En prensa.
Sanchez S and Demain AL.
Useful Microbial Enzymes— An Introduction.
In. Goutham K, Demain AL and Adrio JL (Eds) Biotechnology of Microbial Enzymes. Production, Biocatalysis and Industrial Applications. Elsevier Inc. Chapter 1. Pp. 1-11. ISBN: 9780128037461. DOI: 10.1016/B978-0-12-803725-6.00001-7
Martínez-Klimova, E., Rodríguez-Peña, K. and Sánchez, S.
Endophytes as sources of antibiotics.
Biochemical Pharmacology. En prensa. doi: 10.1016/j.bcp.2016.10.010
Tierrafría, V., y Sánchez, S.
¿Cómo abordar el estudio de una proteína hipotética? el caso de la proteína SCO2127 de Streptomyces coelicolor.
BioTecnología, 20(3): 26- 36.
Sanchez, S. and Demain, A.L.
Bioactive products from fungi.
In: Puri M, MN Puri (Eds.) Food Bioactives: Extraction and Biotechnology Applications. Springer, Cham Switzerland. En Prensa.
|Corina Diana Ceapa||Posdoctoral|
|Brenda Sánchez Salazar||Doctorado|
|Diana Ivonne Rocha Mendoza||Doctorado|
|Karol Rodríguez Peña||Doctorado|
|Silvia Margarita Guzmán Trampe||Doctorado|
|Diana Carolina Bautista Tovar||Maestría|
|Monserrat Manzo Ruiz||Maestría|
|Nidia Maldonado Carmona||Maestría|
|Omar Jiménez Rodríguez||Maestría|
|Luis Ángel Corona Ortega||Licenciatura|