Áreas de Trabajo
En mi laboratorio estamos interesados en la fisiología y fisiopatología renales.
Tenemos líneas de investigación que van desde el manejo renal de sal y la hipertensión arterial, así como en la obesidad e hipertensión y problemas clínicos como al insuficiencia renal aguda o los mecanismo de retención de sal en pacientes con edema.
Trabajamos con transportadores de sal en el riñón que son fundamentales para determinar la excreción urinaria de sal y por lo tanto, son críticos para definir el volumen circulante y la presión arterial. Las alteraciones en estos transportadores producen hiper o hipotensión arterial y bloquearlos con diuréticos es útil para el manejo de esta enfermedad. Estamos particularmente interesados en mecanismo de regulación.
Utilizamos múltiples técnicas que van desde la ingeniería genética hasta la investigación clínica.
Publicaciones Recientes
Publicaciones indizadas: 270. En ingles: 212; Factor de impacto promedio 5.1 ± 0.4. Citas totales: 18,813, con índice h de 66.
Gamba G.
Thirty years of the NCC cotransporter: from cloning to physiology and structure
Am J Physiol Renal Physiol, 325:F479-F490
2023
Trejo F, Elizalde S, Mercado A, Gamba G, and de los Heros P.
SLC12A Cryo-EM: Analysis of relevant ion binding sites, structural domains and amino acids.
Am J Physiol Cell Physiol, 325:C921-C939
2023
Chavez-Canales M, Garcia JA & Gamba G.
Regulation of the WNK4-SPAK-NCC pathway by the calcium-sensing receptor.
Curr Op Nephrol Hypert 32:451-457
2023
Moreno E, Pacheco-Alvarez D, Chavez-Canales M, Elizalde S, Leyva-Ríos K & Gamba G.
Structure-Function Relationships in the Sodium Chloride Cotransporter.
Frontiers in Physiology, 14:1118706, 1-8
2023
Bahena-López JP, Rojas-Vega L, Chávez-Canales M, Lee J-H, Bazua-Valenti S, Bautista R, Lee J-H, Madero M, Vázquez-Manjarrez N, Alquisiras-Burgos I, Hernandez-Cruz A, Castañeda-Bueno M, Ellison DH, & Gamba G.
Glucose/fructose delivery to the distal convoluted tubule induces activation of the NaCl cotransporter via calcium sensing receptor.
J Am Soc Nephrol, 34:55-72
2023
Publicaciones Recientes (continuación)
Gamba G.
Arterial blood pressure, neuronal excitability, mineral metabolism and cell volume regulation mechanisms revealed by Xenopus laevis oocytes.
Membranes, 12, 911, 1-11, DOI: 10.3390/membranes12100911
2022
Murillo-de-Ozores A, Carbajal-Contreras H, Magaña-Avila GR, Valdés R, Grajeda-medcina LI, Vázquez N, Zariñán T, López-Saavedra A, Sharma A, Lin D-H, Wang W-H, Delpire E, Ellison DH, Gamba G & Castañeda-Bueno M.
Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia
Kidney International, 102:1030-1041
2022
Castañeda-Bueno M, Ellison DH & Gamba G.
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule
EMBO Molecular Medicine, 2022 Feb 7;14(2):e14273. doi: 10.15252/emmm.202114273
2022
Chavez-Canales, Maria; Tusie-Luna, Teresa; Gamba, Gerardo; Ostrosky-Frid, Mauricio; Romo, Miriam; Grunfeld, Beatriz; Simsolo, Rosa; Segura-Kato, Yayoi
Familial Hyperkalemic Hypertension Genotype With a Negative Phenotype: A CUL3 Mosaicism
American Journal Of Hypertension, Volume 33 Número 3 Páginas 278 a la 281 DOI: 10.1093/ajh/hpz185
2020
Murillo de Ozores AR, Chávez-Canales M, De los Heros P, Gamba G, Castañeda-Bueno M.
Physiological processes modulated by the chloride-sensitive WNK-SPAK/OSR1 kinase signaling pathway and the cation-coupled chloride cotransporters.
Frontiers in Physiology, 2020 Oct 20;11:585907. doi: 10.3389/fphys.2020.585907
2020
Freundlich M, Gamba G, Rodriguez-Iturbe B. FGF23-Klotho and Hypertension. Experimental and Clinical Mechanisms.
Pediatric Nephrol. En prensa
2020
Argaiz ER, Rola Philliphe & Gamba G. Dynamic changes in portal vein flow during decongestion in patients with heart failure and cardio-renal syndrome.
A POCUS case series.
Cardiorenal Medicine, en prensa
2020
Gonzalez-Duarte A, Kaufer-Horwitz M, Gamba G, Rivera-Moscoso R, Aguilar-Salinas C.
Bioethics in Medical Care rationing during the COVID-19 pandemic.
Clincal and Translational Research, en prensa
2020
Diaz L, Zambrano E, Flores ME, Contreras M, Crispin JC, Alemán G, Bravo C, Armenta A, Valdez J, Tovar A, Gamba G, Barrios J & Bobadilla NA.
Ethics in experimental research involving the use of animals: the principles of 3R’s.
Clinical and Translational Research, en prensa
2020
Louis-Dit-Picard H, et al.
Mutations affecting the conserved acidic motif of WNK1 cause inherited hyperkalemic hyperchloremic acidosis.
J Clin Invest, 2020 Aug 13:94171. doi: 10.1172/JCI94171
2020
McFarlin BE, Chen Y, Priver TS, Ralph DL, Mercado A, Gamba G, Madhur MS, McDonough AA.
Coordinate adaptations of skeletal muscle and kidney to adjust extracellular [K]+ during K+ deficient diet in mice.
Am J Physiol Cell Physol. 319:C757-C770
2020
Pacheco-Alvarez D, Carrillo-Perez DL, Mercado A, Leyva-Rios K, Moreno E, Hernandez-Mercado E, Castañeda-Bueno M, Vazquez N & Gamba G.
WNK3 and WNK4 Exhibit Opposite Sensitivity with Respect to Cell Volume and Intracellular Chloride Concentration.
Am J Physiol Cell Physol, 319: C371-C380
2020
Ostrosky-Frid M, Chávez-Canales M, Romo M, Grunfeld B, Simsolo R, Segura-Cato Y, Tusié-Luna T and Gamba G.
Familiar Hyperkalemic Hypertension Genotype with a Negative Phenotype: a CUL3 mosaicism
Am J Hypert, 33(3):278-281
2020
Guevara-Cruz M, Godinez-Salas ET, Sánchez- Tapia M, Torres-Villalobos G, Pichardo-Ontiveros E, Guizae-Heredia R, Arteaga-Sánchez L, Gamba G, Mojica-Espinosa R, Schcolink-Cabrera A, Granados O, López-Barradas A, Vargas-Castillo A, Torre-Villalvazo I, Noriega LG, Torres N, Tovar AR.
Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscke AMPK activation in obese subjects.
BMJ Open Diabetes Res Care. 2020 Mar;8(1). pii: e000948. doi: 10.1136/bmjdrc-2019-000948
2020
García-Ortuño LE, Barrera-Chimal J, Pérez-Villalva R, Ortega Trejo JA, Luna-Bolaños E, Lima-Posada IQ, Sanchez-Navarro A, Reyes-Castro LA, Gamba G, Zambrano E, Bobadilla NA.
Resilience for acute kidney injury in offspring of maternal protein restriction.
Am J Physiol Renal Physol, 317(6):F1637-F1648
2019
Lanni JS, Peal D, Ekstrom L, Chen H, Stanclift C, Bowen ME, Mercado A, Gamba G, Kahle KT, Harris MP.
Integrated K+ channel and K+-Cl- cotransporter function are required for the coordination of size and proportion during development.
Dev Biol. 30(18):2377-2398
2019
Amaya A, Alarcón L, Martín-Tapia D, Cuellar F, Cisneros B, Rodriguez AJ,
Gamba G & González-Mariscal L.
Activation of the Ca2+ sensing receptor and the downstream PKC/WNK4 signaling cascade induces the arrival of ZO-2 to tight junctions and its separation from 14-3-3.
Mol Biol Cell, 2019 Aug 15;30(18):2377-2398. doi: 10.1091/mbc.E18-09-0591
2019
Sánchez-Navarro A, Pérez-Villalva R, Mejía-Vilet JM, Carrillo-Pérez DL, Marquina-Castillo B, Gamba G and Bobadilla NA.
Serpin A3 in the early recognition of acute kidney injury to chronic kidney disease (CKD) transition in the rat and its potentiality in the recognition of patients with CKD.
Scientific Reports, 9:10350
2019
Moreno E, de los Heros P, Cutler C, Vega-Mateos A, Vázquez N & Gamba G.
Structure and function relationships in the renal NaCl cotransporter NCC
Curr Topics Membr 83:177-201
2019
Murillo-de-Ozores AR, Gamba G, Castañeda-Bueno M.
Molecular mechanisms for the regulation of blood pressure by potassium.
Curr Topics Membr 83:285-313
2019
Ostrosky-Frid M, Castañeda-Bueno M & Gamba G.
Regulation of the NaCl Cotransporter by the WNK4-SPAK Pathway.
Lessons learned from genetically altered animals.
Am J Physiol Renal Physiol. 316:F146-F158
2019
Barrera-Chimal J, Rocha L., Amador-Martínez I, Gonzalez R., Pérez-Villalva R, Cortés-González C, Uribe N, Berman N, Gamba G, Bobadilla N.A.
Delayed spironolactone administration prevents the acute kidney injury to chronic kidney disease transition through improving renal inflammation.
Nephrol Dial Transpl 34:794-801
2019
De los Heros P, Pacheco-Alvarez D & Gamba G.
Role of WNK kinases in the modulation of cell volume.
Curr Topics Membr 81:207-235
2018
Argaiz ER, Chavez-Canales M, Ostrosky-Frid M, Rodríguez-Gama R, Vázquez N, Gonzalez-Rodriguez X, Garcia-Valdes J, Hadchouel J, Ellison D & Gamba G.
The Kidney Specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC.
Am J Physiol Renal Physiol. 315:F734-F745
2018
Murillo-de-Ozores AR, Rodríguez-Gama A, Bazúa-Valenti S, Leyva-Ríos K, Vázquez N, Pacheco-Álvarez D, De La Rosa-Velázquez I, Wengie A, Stone KL, Loffing J, Lifton RP, Yang C-L, Ellison DH, Gamba G, & Castañeda-Bueno M.
C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity.
J Biol Chem, 293: 12209-12221
2018
Gamba G.
Remembering Steve Hebert.
Am J Physiol Cell Physiol. 315:C122-C123
2018
Bazua-Valenti S, Rojas-Vega L, Castañeda-Bueno M, Barrera-Chimal J, Bautista R, Cervantes-Pérez LG, Vázquez N, Plata C, González-Mariscal L, Murillo-de-Ozores AR, Ellison DH, Riccardi D, Bobadilla NA & Gamba G.
The Calcium-sensing Receptor Increases Activity of the Renal NaCl Cotransporter Through the WNK4-SPAK Pathway.
J Am Soc Nephrol, 29:1838-1848
2018
Terker A, Castaneda-Bueno M, Ferdaus M, Cornelius R, Erspamer K, Su X-T, Miller L, McCormick J, Wang W-H, Gamba G, Yang C-L, and Ellison D.
With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo
Am J Physiol Renal Physiol. 315:F781-F790
2018
Moreno E, Gayosso J, Montejano JR, Almaguer G, Vázquez N, Cruz C, Mercado A, Bobadilla NA, Gamba G, Sierra A & Ramírez V.
Geraniin is a diuretic by inhibiting the Na+:K+:2Cl- cotransporter, NKCC2.
Am J Physiol Renal Physiol. 314:F240-F250
2018
Torre-Villalvazo I, Cervantes-Pérez LG, Noriega LG, Jimenez JV, Uribe N, Chávez-Canales M, Tovar-Palacio C, Marfil-Garza BA, Torres N, Bobadilla NA, Tovar AR & Gamba G.
Inactivation of SPAK kinase reduces body weight gain in mice fed a High-fat diet by improving energy expenditure and insulin sensitivity.
Am J Physiol Endocrinol Metabolism. 314:E53-E65
2018
Cervantes- Pérez LG, Castañeda-Bueno M, Jimenez V, Vázquez N, Rojas-Vega L, Alessi D, Bobadilla NA & Gamba G.
Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II.
Journal of Hypertension, 18:361-367
2018
Rosenbaek LL, Rizzo F, Wu Q, MacAulay N, Rojas-Vega L, Gamba G, Staub O, and Fenton RA.
The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation
Scientific Report. 7, 12981, DOI:10.1038/s41598-017-12819-0
2017
Lima-Posada I, Portas-Cortés C, Pérez-Villalva R, Fontana F, Rodríguez-Romo R, Prieto R, Sánchez-Navarro A, Rodríguez-González GL, Gamba G, Zambrano E & Bobadilla NA.
Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition.
Scientific Report. 7: 12270 | DOI:10.1038/s41598-017-09630-2
2017
Matus-Ortega ME, Leff Gelman P, Calva-Nieves JC, Flores-Zamora A, Acevedo-Ortuño R, Salazar-Juárez A, Torner-Aguilar CA, Gamba G, De Los Heros P, Peng B, Pintar JE, Gompf HS, Allen CN, Alagón-Cano A, & Antón-Palma B.
Mexneurin a novel precursor of peptides in the central nervous system of rodents.
FEBS Letters, 591:1627–1636
2017
Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough III O, Shibata S, Rojas-Vega L, Gamba G, Rinehart J, Lifton R.
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
Proc Natl Acad Sci USA. 114:E879-E886
2017
Barba-Navarro R, Tapia-Silva M, Garza-Garcia C, López-Giacoman S, Melgoza-Toral I, Vázquez-Rangel A, Bobadilla NA, Baranda F, Chawla LS, Gamba G & Madero M.
The Effect of Spironolactone on Acute Kidney Injury after Cardiac Surgery. A Randomized Placebo Controlled Trial.
Am J Kid Dis. 69:192-199
2017
Moreno E, Plata C, Rodríguez-Gama A, Argaiz ER, Vázquez, Leyva-Ríos K, Islas L, Cutler C, Pacheco-Alvarez D, Mercado A, Cariño R, Castañeda-Bueno M, & Gamba G.
European Eel NCCb is a Thiazide-resistant Na+:Cl- Cotransporter.
J Biol Chem. 291, 22472-22481
2016
López-Barradas A, González-Cid T, Vázquez N, Gavi-Maza M, Reyes-Camacho A, Velázauez-Villegas L, Ramirez V, Zandi-Nejad K, Mount D, Torres N, Tovar A, Romero M, Gamba G & Plata C.
Insulin and SGK1 reduce the function of Na+/Monocarboxylate Transporter 1 (SMCT1/SLC5A8).
Am J Physiol Cell Physiol. 311:C720-C734
2016
Argaiz ER & Gamba G.
On the molecular mechanism of renal salt excretion modulation by extracellular potassium.
J Physiol. 594:6071-6072
2016
Ferdaus M, Barber K, López-Cayuqueo K, Terker A, Argaiz E, Gassaway B, Chambrey R, Gamba G, Rinehart J, and McCormick J.
SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.
J Physiol. 549:4945-4966
2016
Argaiz ER & Gamba G.
The regulation of NCC by WNK4.
Curr Op Nephrol Hypert. 25:417-423
2016
Mercado A, de los Heros P, Melo Z, Chavez-Canales M, Murillo A, Moreno E, Bazúa-Valenti S, Vázquez N, Hadhouel J & Gamba G.
With no lysine L-WNK1 isoforms are negative regulators of the K+:Cl- cotransporters.
Am J Physiol Cell Physiol. 311:C54-C66
2016
Bazúa-Valenti S, Castaneda-Bueno M & Gamba G.
Physiological Role of SLC12 Family Members in the Kidney.
Am J Physiol Renal Physiol. 311:F131-F144
2016
Gamba G.
The Evolving Field of Salt Transport Regulation in the Steve Hebert Lecture.
Am J Physiol Renal Physiol. 311:F68-F70
2016
Ellison DH, Terker AS, Gamba G.
Potassium and Its Discontents: New Insight, New Treatments.
J Am Soc Nephrol 27:981-989
2016
Merner ND, Mercado A, Khanna AR, Hodgkinson A, Bruat V, Awadalla P, Gamba G, Guy A. Rouleau GA, Kahle KT.
Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia.
J Psychiatric Res, 77:22-26
2016
Hadchouel J, Ellison DH, Gamba G.
Regulation of Renal Electrolyte Transport by WNK and SPAK/OSR1 Kinases.
Annu Rev Physiol. 78:367-389
2016
Rodríguez-Romo R, Benítez K, Barrera-Chimal J, Pérez-Villalva R, Gómez A, Aguilar-León D, Rangel-Santiago JF, Huerta S, Gamba G, Uribe N, Bobadilla NA.
AT1 receptor antagonism before ischemia prevents the transition from acute kidney injury to chronic kidney disease.
Kidney International. 89:363-373
2016
Terker AS, Zhang C, Erspamer KJ, Gamba G, Yang C-L & Ellison DH.
Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis.
Kidney International. 89:127-134
2016
Rojas-Vega L & Gamba G.
Hormonal regulation of the renal NaCl cotransporter.
Am J Physiol Renal Physiol. 310:F10-F14
2016
Ortega JA, Pérez-Villalva R, Barrera-Chimal J, Flores ME, Gamba G & Bobadilla NA.
Heat Shock Protein 72 (Hsp72) Specificity and Temporal Stability in Urine Samples as a Reliable Biomarker of Acute Kidney Injury (AKI).
Biomarkers. 20:453-459
2015
Rojas-Vega L, Jiménez AR, Bazúa-Valenti S, Arroyo-Garza I, Jiménez JV, Gómez-Ocádiz R, Carrillo-Pérez DL, Moreno E, Morales-Buenrostro LE, Alberú J,
& Gamba G.
Increased phosphorylation of the renal Na+-Cl- cotransporter in kidney transplant recipient patients with hypertension: a prospective cohort
Am J Physiol Renal Physiol. 309:F836-F842
2015
Bazúa-Valenti S, Chávez-Canales M, Rojas-Vega L, Vázquez N, Rodriguez-Gama A, Melo Z, Plata C, Ellison DH, Hadchouel J & Gamba G.
The effect of WNK4 on the NaCl cotransporter is modulated by intracellular chloride.
J Am Soc Nephrol. 26:1781-1786
2015
Bazúa-Valenti S & Gamba G.
Revisiting the NaCl cotransporter regulation by the with no lysine kinases.
Am J Physiol Cell Physiol, 308:C779-C791
2015
Rojas-Vega L, Reyes-Castro LA, Ramirez V, Bautista R, Rafael C, Castañeda-Bueno M, Meade P, De los Heros P, Arroyo-Garza I, Bernard V, Binart N, Hadchouel J, Bobadilla NA, Zambrano E & Gamba G.
Ovarian Hormones and Prolactin Increase the Renal NaCl Cotransporter Phosphorylation.
Am J Physiol Renal Physiol, 308:F799-F808
2015
Takeuchi Y, Mishima E, Shima H Akiyama Y, Suzuki C, Suzuki T Kobayashi T, Suzuki Y, Nakayama T, Takeshima K, Vazquez N, Ito S, Gamba G, & Takaaki A.
Exonic Mutations in the SLC12A3 Gene Cause Exon Skipping and Premature
Termination in Gitelman’s Syndrome.
J Am Soc Nephrol. 26:271-279
2015
McCormick JA, Yang CL, Zhang C, Davidge B, Katharina B, Terker A, Yarborogh B, Meermeier N, Park H-J, McCully B, West M, Borschewski A, Himmikus N, Bleich M, Bachmann S, Mutig K, Argaiz E, Gamba G, Singer J, Ellison DH.
Dominant CUL3 mutations degrade KLHL3 to promote WNK signaling in hyperkalemic hypertension
J Clin Invest, 124:4723-4736
2014
Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G & Hadchouel J.
The WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the NaCl cotransporter via SPAK, an effect antagonized by WNK4
Hypertension, 64:1047-1053
2014
Lagnaz D, Arroyo JP, Chávez-Canales M, Vázquez N, Rizzo F, Spirlí A, Debonneville A, Staub O, Gamba G. WNK3 abrogates the Nedd4-2-mediated inhibition of the renal NaCl cotransporter.
Am J Physiol Renal Physiol, 307:F275-F286
2014
Castañeda-Bueno M, Cervantes-Perez L, Rojas-Vega L, Arroyo-Garza I, Vázquez N, Moreno E, & Gamba G.
Modulation of NCC activity by low and high K+ intake: insight into the signaling pathways involved.
Am J Physiol Renal Physiol, 306:F1507-F1519
2014
Gamba G.
Regulation of NKCC2 activity by SPAK truncated isoforms.
Am J Physiol Renal Physiol, 306:F49-F50
2014
Barrera-Chimal J, Pérez-Villalva R, Ortega J.A., Uribe N, Gamba G, Cortés-González C & Bobadilla N.A.
Intra-renal transfection of heat shock protein 90 alpha or beta (Hsp90 or Hsp90 protects against ischemia/reperfusion injury
Nephrol Dial Transp, 29:301-312
2014
Moguel-Gonzalez B, Wasung-de-Lay M, Tella-Vega P, Riquelme-Mc-Loughlin C, Villa AR, Madero M y Gamba G.
Acute kidney Injury in cardiac surgery.
Rev. Invest. Clin. 65:467-475
2013
Melo Z, Cruz-Rangel S, Bautista R, Vázquez N, Mount DB, Mercado A and Gamba G.
Molecular evidences for K-Cl cotransporters role in the kidney.
Am J Physiol Renal Physiol, 305:F1402-F1411
2013
Shibata S, Rinehart J, Zhang J, Moeckel G, Castañeda-Bueno M, Stiegler AL, Boggon TJ, Gamba G, and Lifton RP.
Mineralocorticoid receptor phosphorylation regulates ligand binding and receptor activation.
Cell Metabolism, 18:660-671
2013
Melo Z, de los Heros P, Cruz-Rangel S, Vazquez N, Bobadilla NA, Alessi DR, Morales-Pasantes H, Mercado A & Gamba G.
N-terminal serine dephosphorylation is required for full activation of KCC3 during cell swelling.
J Biol Chem, 288:31468-31476
2013
Arroyo JP, Kahle KT & Gamba G.
The SLC12 family of electroneutral cation-coupled chloride cotransporters.
Molec Asp Med, 34:288-298
2013
Chávez-Canales M, Arroyo JP, Ko B, Vázquez N, Bautista R, Castañeda-Bueno M, Bobadilla NA, Hoover R & Gamba G.
Insulin Increases the Functional Activity of the NaCl cotransporter.
J. Hypertension, 31:303-311
2013
Barrera-Chimal J, Pérez-Villalba R, Rodríquez-Romo R, Reyna J, Uribe N, Gamba G & Bobadilla NA.
Spironolactone prevents chronic kidney disease as a consequence of an ischemic acute kidney injury episode.
Kidney International, 83:93-103
2013
Gamba G.
Regulation of the renal NaCl cotransporter by phosphorylation and ubiquitylation.
Am J Physiol Renal Physiol, 303:F1573-F1583
2012
Cruz-Rangel S, Gamba G, Ramos-Mandujano G & Pasantes-Morales H.
Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells.
Pfluger Arch, 464:317-330
2012
Castañeda-Bueno M & Gamba G.
Mechanisms of NCC modulation by angiotensin II.
Curr Op Nephrol Hyperten, 21:516-522
2012
Sánchez-Pozos K, Barrera-Chimal J, Garzón-Muvdi J, Pérez-Villalva R, Rodríguez-Romo R, Cruz C, Gamba G & Bobadilla NA.
Recovery from ischemic acute kidney injury by spironolactone administration.
Nephrol Dial Transp, 27:3160-3169
2012
Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantsaria S, Morla L, Bobadilla NA, Doucet A, Alessi DR & Gamba G.
The activation of the renal Na-Cl cotransporter by angiotensin II is a WNK4 dependet process in the mouse.
Proc Natl Acad Sci USA, 109:7929-7934
2012
Arroyo JP & Gamba G.
Advances in WNK signaling of salt and potassium metabolism — clinical implications of basic findings.
Am J Nephrol, 35:379-386
2012
Castañeda-Bueno M, Arroyo JP & Gamba G.
Independent regulation of Na+ and K+ balance by the kidney
Medical Principles and Practice, 21:101-114
2012
Pacheco-Alvarez D, Vázquez N, Castañeda-Bueno M, De-los-Heros P, Cortes C, Moreno E, Meade P, Bobadilla NA & Gamba
WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family.
Cellular Physiology and Biochemistry. 29:291-302
2012
Pacheco-Alvarez D, & Gamba
WNK3 is a putative chloride sensitive kinase.
Cellular Physiology and Biochemistry. 28:1123-1134
2011
Mutig K, Kahl T, Saritas T, Godes M, Persson P, Bates J, Rampoldi L, Uchida S, Hille C, Dosche C, Kumar SW, Castañeda-Bueno M, Gamba G, & Bachmann S.
Activation of the bumetanide-sensitive Na+,K+,2Cl–cotransporter NKCC2 is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner
J. Biol. Chem. 286:30200-30210
2011
Rinehart J, Vázquez N, Kahle K, Hodson CA, Ring A, Gulcicek E, Louvi A, Bobadilla NA, Gamba G, & Lifton RP
WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters
J. Biol. Chem. 286:30171-30180
2011
Cruz-Rangel S, Melo Z, Vazquez N, Meade P, Ponce-Coria, Bobadilla NA, Pasantes-Morales H, Gamba G, Mercado A..
Similar effects of all WNK3 variants upon SLC12 transporters
Am J Physiol Cell Physiol 301:C601-C608
2011
Arroyo JP, Lagnaz D, Ronzaud C, Vazquez N, Ko, B, Moddes L, Ruffieux- Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G & Staub O.
The renal Na+:Cl- cotransporter is regulated by the aldosterone-SGK1-Nedd4-2 Pathway.
J Am Soc Nephrol. 22:1707-1719
2011
Arroyo JP, Lagnaz D, Ronzaud C, Staub O & Gamba G.
The aldosterone paradox: differencital regulation of ion transport system in the distal nephron.
Physiology. 26:115-123
2011
Barrera-Chimal J, Pérez-Villalba R, Ojeda-Cervantes M, Gamba G, Morales-Buenrostro LE y Bobadilla NA.
Hsp72 is an early and sensitive biomarker to detect acute renal injury.
EMBO Mol Med, 3:5-20
2011
Acuña R, Martínez-de-la-Maza L, Ponce-Coria J, Vázquez N, Ortal-Vite P, Pacheco-Alvarez D, Bobadilla NA & Gamba G.
Rare mutations in slc12a1 and slc12a3 protect against hypertension by reducing the activity of renal salt cotransporters
Journal of Hypertension 29:475-483
2011
Castañeda-Bueno M, Vázquez N, Bustos I, Hernández D, Rodríguez-Lobato E, Pacheco-Alvarez D, Cariño-Cortes R, Moreno E, Bobadilla NA, & Gamba G.
A Single Residue in Transmembrane Domain 11 Defines the Different Affinity for Thiazides between the Mammalian and Flounder NaCl Transporter
Am J Physiol Renal Physiol. 299:F1111-F1119
2010
Cortés-Gonzalez C, Barrera-Chimal J, Ibarra-Sánchez M, Gilbert M, Gamba G, Zentella A, Flores ME & Bobadilla NA.
Opposite effect of Hsp90α and Hsp90β on eNOS ability to produce Nitric Oxide or Superoxide Anion
Cellular Physiology and Biochemistry, 26:657-668
2010
Gamba G.
The nanopeptide hormone vasopressin is a new regulator of the thiazide-sensitive Na+:Cl- cotransporter.
Kidney International, 78:127-129
2010
Sáncehz Pozos K, Lee-Montiel F, Pérez R, Uribe N, Gamba G, Bazan B & Bobadilla NA.
Polymerized type I collagen reduces chronic cyclosporine nephrotoxicity
Nephrol Dial Transp 25:2150-2158
2010
Gamba G.
Vasopressin regulates the renal Na-Cl cotransporter.
Am J Physiol Renal Physiol. 298:F500-F501
2010
Castañena-Bueno M & Gamba G.
SPAKling insight into blood pressure regulation.
EMBO Molecular Medicine, 2:39-41
2010
Ramírez V, Trujillo J, Valdés R, Uribe N, Cruz C, Gamba G y Bobadilla NA. Adrenalectomy prevents renal ischemia/reperfusion injury.
Am J Physiol Renal Physiol. 297:F932-F942
2009
Gamba G.
The Thiazide-sensitive Na+:Cl- Cotransporter: molecular biology, functional properties, and regulation by WNKs.
Am J Physiol Renal Physiol. 297:F838-F848
2009
Gamba G & Friedman PA.
Thick ascending limb of Henle: The Na+:K+:2Cl- cotransporter NKCC2 and the Calcium sensing receptor, CaSR.
Pflugers Archives, 458:61-67
2009
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring A, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, & Gamba G.
Angiotensin II Signaling Increases Activity of the Renal Na-Cl Cotransporter Through a WNK4-SPAK – Dependent Pathway.
Proc Natl Acad Sci USA. 106:4384-4389
2009
Trujillo J, Cruz C, Tovar A, Vaidya V, Bonventre J, Gamba G, Torres N, Bobadilla NA.
Renoprotective mechanisms of soy protein intake in obsese Zucker rats.
Am J Physiol Renal Physiol, 295:F1574-F1582
2008
San Cristobal P, Ponce-Coria J, Vazquez N, Bobadilla NA & Gamba G.
WNK3 and WNK4 amino terminal domain defines their effect on the renal Na+:Cl- cotransporter
Am J Physiol Renal Physiol, 295:F1199-1206
2008
Ramírez V, Mejía-Villet J, Hernández de Santiago D, Gamba G, Bobadilla NA.
Radicicol, a Heat Shock Protein 90 (Hsp90) Inhibitor Reduces Glomerular Filtration Rate
Am J Physiol Renal Physiol, 295:F1044-1051
2008
Kahle KT, Staley KJ, Nahed BV, Gamba G, Hebert SC, Lifton RP & Mount DB.
Roles of the cation–chloride cotransporters in neurological disease
Nature Clin Pract Neurol 4:490-503
2008
Welker P, Böhlick A, Mutigi K, Salanova M, Kahl T, Schlüterz H, Clottner D, Ponce-Coria J, Gamba G & Bachmann S.
Renal Na+:K+:2Cl- cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent.
Am J Physiol Renal Physiol. 295:F789-F802
2008
San-Cristobal P, de los Heros P, Ponce-Coria J, Moreno E & Gamba G.
WNK kinases, renal ion transport and hypertension.
Am J Nephrol 28:860-870
2008
Ponce-Coria J, San Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de los Heros P, Muñoz E, Juarez P, Michel G, Rivera J, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC & Gamba G.
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
Proc Natl Acad Sci. 105:8458-8463
2008
Kahle KT, Wilson FH, Ring AM, Rinehart J, Gimenez I, Giebisch G, Gamba G, Hebert SC, and Lifton RP.
A novel protein kinase signaling pathway essential for blood pressure regulation in humans.
Trends in Endocrinology and Metabolism. 19:91-95
2008
Ko B, Joshi LM, Cooke LL, Vazquez N, Musch MW, Hebert SC, Gamba G & Hoover RS.
Phorbol ester stimulation of Ras-GRP1 regulates the sodium chloride cotransporter via a PKC-independent pathway.
Proc Natl Acad Sci. 104:20120-20125
2007
Benziane B, Demaretz S, Defontaine N, Zaarour N, Cheval L, Bourgeois S, Klein C, Froissart M, Blanchard A, Paillard M, Gamba G, Houillier P, & Laghmani K.
NKCC2 Surface Expression in Mammalian cells: Down-Regulation by Novel interaction with Aldolase B
J. Biol. Chem. 282:33817-33830
2007
Dvorak MM, de Joussineau C, Carter DH, Pisitkun T, Knepper MR, Gamba G, Kemp PJ, & Riccardi D.
An osteoblast sodium chloride cotransporter, SLC12A3, mediates the bone-protective effects of thiazide diuretics.
J.Am. Soc. Nephrol. 18:2509-2516
2007
Bobadilla NA & Gamba G. New insights into Pathophysiology of Cyclosporine Nephrotoxicity: A role of aldosterone.
Am J Physiol Renal Physiol 293:F2-F9
2007
Mejía-Villet J, Ramírez V, Cruz C, Uribe N, Gamba G, Bobadilla NA.
Renal ischemia/reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone
Am J Physiol Renal Physiol 293:F78-F83
2007
Martínez-Barnetche J, Garcia-Solache M, Neri-Lecona A, Tello-Lopez A, Gamba G, Vazquez N, Rodríguez MR, Lanz-Mendoza H.
Cloning and functional characterization of the Anopheles albimanus DMT1/NRAMP homolog: Implications in iron metabolism in mosquitoes.
Insect Biochemistry and Molecular Biology 37:532-539
2007
Colmenero-Flores JM, Martínez G, Gamba G, Iglesias DJ, Paneque M, Vázquez N, Brumós J & Talón M.
Identification and functional characterization of cation-Cl- cotransporters in plants.
Plant Journal, 50:278-292
2007
Garzón-Mudvi T, Pacheco-Alvarez D, Gagnon KBE, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, & Gamba G.
WNK4 kinase is a negative regulator of K+-Cl- cotransporters
Am J Physiol Renal Physiol 292:F1197-F1207
2007
Pérez-Rojas J, Blanco JA, Cruz C, Trujillo J, Vaidya VS, Uribe N, Bonventre JV, Gamba G and Bobadilla NA.
Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity.
Am J Physiol Renal Physiol 292: F131-F139
2007
Pacheco-Alvarez D, San Cristóbal P, Meade P, Moreno E, Vázquez N, Muñoz E, Díaz A, Juárez ME, Giménez I y Gamba G.
The Na-Cl cotransporter is activated and phosphorylated at the amino terminal domain upon intracellular chloride depletion
J. Biol. Chem. 281:28755-28763
2006
Kahle KT, Rinehart J, Ring A, Gimenez I, Gamba G, Hebert SC and Lifton RP.
WNK Protein Kinases Modulate Cellular Cl- Flux by Altering the Phosphorylation State of the Na-K-Cl and K-Cl Cotransporters
Physiology. 21:326-335
2006
Moreno E, San Cristobal P, Rivera M, Vázquez N, Bobadilla NA y Gamba G.
Affinity defining domains in the Na-Cl cotransporter: different location for Cl- and thiazide binding.
J. Biol. Chem. 281:17266-17275
2006
Gamba G.
TRPV4: new target of the hypertension related kinases WNK1 and WNK4.
Am J Physiol Renal Physiol. 290:F1303-F1304
2006
Paredes A, Plata C, Rivera M, Moreno E, Vázquez NA, Muñoz-Clares R, Hebert SC & Gamba G.
The activity of the renal Na+:K+:2Cl- cotransporter is reduced by mutagenesis of the N-glycosylation sites. A role for protein surface charge in Cl- transport.
Am J Physiol Renal Physiol. 290:F1094-F1102
2006
De los Heros P, Kahle KT, Rinehart J, Bobadilla NA; Vázquez N, San Cristóbal P, Mount DB, Lifton RP, Hebert SC & Gamba G.
WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway
Proc Natl Acad Sci. 103:1976-1981
2006
Salas-Casas A, Ponce-Balderas A, Garcia-Perez RM, Cortes-Reynosa P, Gamba G, Orozco E, Rodriguez MA.
Identification and functional characterization of EhClC-A, an Entamoeba histolytica ClC chloride channel located at plasma membrane.
Mol Microbiol. 59:1249-1261
2006
Kahle KT, Rinehart J, de los Heros P, Louvi A, Meade P, Vázquez N, Hebert SC, Gamba G, Giménez I & Lifton RP.
WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability.
Proc Natl Acad Sci. 102:16783-16788
2005
Rinehart J, Kahle KT, de los Heros P, Vázquez N, Meade P, Wilson FH, Hebert SC, Giménez I, Gamba G & Lifton RP.
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.
Proc Natl Acad Sci. 102:16777-16782
2005
Mercado A, Vázquez N, Song L, Cortés R, Enck L, Welch R, Delpire E, Gamba G & Mount DB.
Amino-Terminal Heterogeneity in the KCC3 K+:Cl- Cotransporter
Am J Physiol Renal Physiol. 289:F1246-F1261
2005
Perez-Rojas J, Derive S, Blanco JA, Cruz T, Martínez de la Masa L, Gamba G & Bobadilla NA.
Renocortical mRNA expression of vasoactive pathways during spironolactone protective effect in chronic cyclosporine nephrotoxicity
Am J Physiol Renal Physiol. 289, F1020-F1030
2005
Gamba G.
WNK lies upstream of kinases involved in regulation of ion transporters.
Biochem J. 391(Pte 1): e1-e3
2005
Perez-Rojas J, Blanco JA, Gamba G & Bobadilla NA.
Low Calorie Commercial Sugar is a Sensitive Marker of Glomerular Filtration Rate
Kidney International 68:1888-1893
2005
Gamba G.
Molecular Physiology and Pathophysiology of the electroneutral cation-chloride cotransporters.
Physiological Reviews. 85:423-493
2005
Gamba G.
Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension.
Am J Physiol Renal Physiol. 288:F245-F252
2005
Trujillo J, Ramírez V, Torre-Villalvazo I, Torres N, Tovar AR, Muñoz RM, Uribe N, Gamba G & Bobadilla NA.
Renal protection by soy protein in obese Zucker rats is associated with restoration of nitric oxide generation
Am J Physiol Renal Physiol 288:F108-F116
2005
Tovar-Palacio C, Bobadilla NA, Cortes P, Plata C, de los Heros P, Vázquez N & Gamba G.
Ion and diuretic specificity of chimeric proteins between apical Na+:K+:2Cl- and Na+:Cl- cotransporters.
Am J Physiol Renal Physiol 287:F570-F577
2004
Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, Vazquez N, Ellison DH & Gamba G.
Pathophysiology of Functional Mutations of the Thiazide-sensitive Na-Cl Cotransporter in Gitelman Disease.
Am J Physiol Renal Physiol 287:F195-F203
2004
Ramírez V, Uribe N, Garcia-Torres R, Castro C, Rubio J, Gamba G & Bobadilla NA.
Up-regulation and Intrarenal Redistribution of Heat Shock Proteins 90 and 90 by Low Sodium Diet.
Cell Stress & Cheprons: 9:198-206
2004
Moreno E, Tovar-Palacio C, de los Heros P, Guzman B, Bobadilla NA, Vázquez N, Riccardi D, Poch E & Gamba G.
A Single Nucleotide Polymorphism Alters the Activity of the Renal Na+:Cl- Cotransporter and Reveals a Role for Transmembrane Segment 4 in Chloride and Thiazide Affinity.
J. Biol. Chem. 279: 16553-16560
2004
Plata C, Escamilla J, Carillo E, Galindo JM, Gamba G, García MC y Sanchez JA.
AKAP79 increases the functional expression of skeletal muscle Ca2+ Channels in Xenopus oocytes.
Biochemical Biophysical Research Communications 316:189-194
2004
Mercado A, Mount DB & Gamba G.
Electroneutral cation-chloride cotransporter gene family in the central nervous system.
Neurochemical Research 29:17-25
2004
Hebert SC, Mount DB & Gamba G.
Molecular physiology of Cation-coupled chloride cotransport: the SLC12 family.
Pflugers Arch 447:580-593
2004
Gamba G.
Analogy for Explaining Intermediate Metabolism.
Am J Physiology Advances in Physiology Education. 27:156-157
2003
Meade P, Hoover R, Plata C, Vazquez N, Bobadilla NA, Gamba G & Hebert SC.
Cyclic-AMP dependent activation of the renal-specific Na-K-2Cl cotransporter is mediated by an NKCC2-(BSC1)-isoform-specific regulation of cotransporter trafficking.
Am J Physiol Renal Physiol 284:F1145-F1154
2003
Hoover R, Poch E, Monroy A, Vazquez N, Nishio T, Gamba G & Hebert SC.
N-Glycosylation at Two Sites Critically Alters Thiazide Binding and Activity of the Rat Thiazide-sensitive Na+:Cl Cotransporter
J.Am. Soc. Nephrol. 14:271-282
2003
Wilson FH, Kahle KT, Sabath E, Lalioti M, Rapson AK, Hoovert RS, Hebert SC, Gamba G, and Lifton RP.
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.
Proc Natl Acad Sci. 100:680-684
2003
Feria I, Pichardo I, Juárez P, Ramírez V, González M, Uribe N, García-Torres R, López-Casillas F, Gamba G & Bobadilla NA.
Therapeutic Benefit of Spironolactone in Experimental Chronic CsA Nephrotoxicity.
Kidney Int. 63:43-52
2003
Song L, Mercado A, Vázquez, Xie Q, Desai R, George A, Gamba G & Mount DM.
Molecular, Functional, and Genomic Characterization of the Human Neuronal K-Cl Cotransporter, hKCC2.
Mol. Brain Res. 103:91-105
2002
Plata C, Meade P, Vázquez N, Hebert SC & Gamba G.
Functional Properties of the Apical Na-K-2Cl Cotransporter Isoforms.
J. Biol. Chem. 277:11004-11012
2002
Vázquez N, Monroy A, Dornates E, Muñoz-Clares RA & Gamba G.
Functional Differences Between the Flounder and Rat Thiazide-sensitive Na+:Cl- Cotransporter
Am J Physiol Renal Physiology 282:F599-F607
2002
Gamba G.
Alternative Splicing and the Diversity of Renal Transporters.
Am J Physiol Renal Physiology 281:F781-F794
2001
Mount DB & Gamba G.
Renal Potassium-Chloride Cotransporters.
Curr Op Nephrol Hypertens 10:685-691
2001
Mercado A, De los Heros P, Vázquez N, Meade P, Mount DB & Gamba G.
Functional and Molecular Characterization of the K-Cl Cotransporter of Xenopus laevis Oocytes.
Am J Physiol Cell Physiol 281:C670-C680
2001
Cueto-Manzano A, Gamba G & Correa-Rotter R.
Peritoneal protein loss in patients with high peritoneal permeability. comparison between continuous ambulatory peritoneal dialysis and daytime intermittent peritoneal dialysis.
Arch Med Res. 32:197-201
2001
Salvador C, Martinez M, Mora SI, Farias JM, Gamba G y Escobar LI.
An Inactivating GIRK5 Inward Rectifying K+ Channel From Xenopus oocytes Conforms a G-Protein-Independent Gated Homomultimer.
Biochem Biophys Acta 1512:135-147
2001
Plata C, Meade P, Hall A, Welch RC, Vázquez N, Hebert SC & Gamba G.
Alternatively Spliced Isoform of the Apical Na-K-Cl Cotransporter Gene in Thick Limb Encodes a Furosemide-Sensitive Na+:Cl- Cotransporter
Am. J. Physiol: Renal Physiol. 280:F575-F582
2001
Moreno G, Bobadilla NA, Rodríguez-Hicks A, González-Salazar J, Mercado A, Tapia E, Hong E, Herrera-Acosta J & Gamba G.
Thiazide-sensitive cotransporter mRNA expression is not altered in three models of hypertension.
Kidney & Blood Pressure Res. 24:57-63
2001
Cueto-Manzano A, Gamba G & Correa-Rotter R.
Quantification and Characterization of Protein Loss in Continuous Ambulatory Peritoneal Dialysis.
Rev Invest Clin. 52: 611-617
2000
Sanchez-Lozada LG, Gamba G, Bolio A, Jiménez F, Herrera-Acosta J y Bobadilla NA.
Nifedipine Prevents the Changes in Nitric Oxide Synthases mRNA Levels Induced by Cyclosporin.
Hypertension, 36:642-47
2000
Mercado A, Song L, Vázquez N, Mount DB & Gamba G.
Functional comparison of the K+:Cl- cotransporters KCC1 and KCC4.
J. Biol. Chem. 275:30326-30334
2000
Gamba G.
Electroneutral Cl-Coupled Cotransporters.
Curr Op Nephrol Hyperten 9:535-40
2000
Merino A, Moreno G, Mercado A, Bobadilla NA y Gamba G.
Na+:K+:ATPase mRNA Expression in the kidney during adaptation to sodium intake and furosemide treatment.
Arch. Med. Res., 31:486-492
2000
Lang F, Klingel K, Wagner CA, Stegen C, Wärntges S, Lanzendörfer M, Melzig J, Moschen I, Fillon S, Steuer S, Waldegger S, Sauter M, Kandolf R, Paulmichl M, Cohen P, Gerke V, Rossier B, Risler T, Gamba G, Capa¬sso G, Hebert SC, Massry SG, & Broer S.
Deranged transcriptional regulation of cell volume sensitive kinase h-sgk in diabetic nephropathy.
Proc Natl Acad Sci. 97:8157-8162
2000
Monroy A, Plata C, Hebert SC & Gamba G.
Characterization of the Thiazide-sensitive Na-Cl Cotransporter: A New Model for Interaction of Ions and Diuretics
Am. J Physiol Renal Physiol: 279:F161-F169
2000
Plata C, Rubio V y Gamba G.
Protein kinase C activation reduces the function of the Na+:K+:2Cl cotransporter in Xenopus laevis oocytes.
Arch. Med. Res., 31:21-27
2000
Riccardi D & Gamba G.
The physiology and pathophysiology of the calcium sensing receptor.
Arch. Med. Res 30:436-448
1999
Gamba G.
Molecular biology or distal nephron sodium transport mechanisms.
Kidney International, 56:1606-1622
1999
Monroy A, Plata C, Gamba G, Droy-Lefaix MT, Garay RP.
Effect of cicletanine on the renal thiazide-sensitive Na+:Cl- cotransporter.
Arch Mal Coeur Vaiss 92:1001-4
1999
Bobadilla NA, Tapia E, Jiménez F, Sánchez-Lozada LG, Santamaría J, Monjardín A, Bolio A, Gamba G and Herrera-Acosta J.
Dexamethasone increases renal endothelial nitric oxide synthase gene expression and prevents cyclosporine nephrotoxicity.
Am. J. Physiol Renal Physiol 277:F464-F471
1999
Mount D, Mercado A, Song L, Xu J, George AL Jr., Delpire E and Gamba G.
Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.
J.Biol. Chem, 274:16355-16362
1999
Plata C, Mount DB, Rubio V, Hebert SC y Gamba G.
Isoforms of the Na-K-2Cl cotransporter in TAL. II. Functional characterization and activation by cyclic-AMP.
Am. J. Physiol Renal Physiol, 276:F359-F366
1999
Mount DB, Baekgaard A, Plata C, Hall AE, Villanueva Y, Kaplan MR, Plotkin MD, Beier DR, Gamba G y Hebert SC.
Isoforms of the Na-K-2Cl transporter in TAL. I. Molecular characterization and intra-renal localization.
Am. J. Physiol Renal Physiol, 276:F347-F358
1999
Mount DB, Delpire E, Gamba G, Hall A, Poch E, Hoover Jr R y Hebert SC.
The electroneutral cation-chloride cotransporters.
J. Exp. Biol. 201:2091-102
1998
Bobadilla NA, Gamba G, Tapia E, García-Torres R, Bolio A, López-Zetina P y Herrera-Acosta J.
Role of NO Synthesis in Cyclosporine Nephrotoxicity. Effects of Chronic NO inhibition and NO Synthases Gene Expression.
Am. J. Physiol Renal Physiol, 274:F791-8
1998
Moreno G, Merino A, Mercado A, Herrera JP, González-Salazar J, Correa-Rotter R, Hebert SC y Gamba G.
Electroneutral Na-coupled cotransporters expression in the kidney during variation in NaCl and water metabolism.
Hypertension. 31:1002-6
1998
Bobadilla NA, Herrera JP, Merino A, Gamba G.
Semi-quantitative PCR: a tool to study low abundance messages in the kidney.
Arch. Med. Res. 28:55-61
1997
Hebert SC, Gamba G y Kaplan MR.
The electroneutral Na+-(K+)-Cl- cotransport family.
Kidney Int. 49: 1638-41
1996
Kaplan MR, Mount DB, Delpire E, Gamba G & Hebert SC.
Molecular mechanisms of NaCl transport.
Annu Rev Physiol. 58:649-68
1996
Hebert SC & Gamba G.
Molecular cloning and characterization of the renal diuretic-sensitive electroneutral sodium-(potassium)-chloride cotransporter.
Proc. Assoc. Am. Physic. 107:76-80
1995
Cueto-Manzano A, Gamba G, Abasta M & Correa-Rotter R.
Consistency of the peritoneal equilibrium test in a cohort of non-selected Mexican CAPD patients.
Adv. Perit. Dial. 11:114-8
1995
Riccardi D, Park J, Lee W-S, Gamba G, Brown EM y Hebert SC.
Cloning and functional expression of a rat kidney extracellular calcium-sensing receptor.
Proc. Natl. Acad. Sci. USA, 92:131-5
1995
Contreras AM, Ramirez M, Cueva L, Alvarez S, Loza R y Gamba G.
Low serum albumin concentration and the increased risk of amikacin nephrotxocicity.
Rev Invest Clin 46:37-43
1994
Hebert SC & Gamba G.
Molecular cloning and characterization of the renal diuretic-sensitive electroneutral sodium-(potassium)-chloride cotransporter.
Clin. Investig., 72:692-4
1994
Diaz-Alvarenga A, Abasta-Jimenez M, Bravo B, Gamba G & Correa-Rotter R.
Serum albumin and body surface are the strongest predictors of the peritoneal transport type.
Adv. Perit. Dial. 10:47-51
1994
Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee W-Se, Hedigher MA & Hebert SC.
Molecular cloning, primary structure and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
J Biol. Chem., 269:17713-22
1994
Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger M, Lytton J & Hebert SC.
Cloning and characterization of an extracellular Ca2+ sensing receptor from bovine parathyroid.
Nature, 366:575-80
1993
Gamba G, Mejía JL, Saldívar S, Correa-Rotter R y Peña JC.
Death risk on CAPD patients. The predictive value of the initial clinical and laboratory variables.
Nephron 65: 23-7
1993
Gamba G, Salzberg SN, Lombardi M, Miyanoshita A, Lytton J, Hediger MA, Brenner BM, and Hebert SC.
Primary structure and functional expression of the cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter.
Proc Natl Acad Sci USA 90: 2749-53
1993
Gamba G, Pedraza-Chaverri J, Cervera J, Cruz C, Hernández-Pando R y Peña JC.
Role of angiotensin II in the sodium retention after acute volume depletion.
Rev Invest Clin 44: 345-52
1992
Gamba G, Reyes E, Angeles A, Quintanilla L, Calva J y Peña JC.
Observer agreement in the scoring of the activity and chronicity indexes of lupus nephritis.
Nephron 57:75-7
1991
Gamba G, Oseguera J, Castrejón M y Gomez-Pérez F.
Bicarbonate therapy in severe diabetic ketoacidosis. A double- blind, randomized, placebo controlled trial.
Rev. Invest. Clin 43: 234-8
1991
Gamba G, Contreras AM, Cortés J, Nares F, Santiago Y, Espinosa A, Bobadilla J, Jimenez-Sanchez G, López G, Valadez A y Peña JC.
Hypoalbuminemia as a risk factor for aminoglycoside nephrotoxicity.
Rev. Invest. Clin 42: 204-9
1990
Cortés J, Gamba G, Contreras AM y Peña JC.
Amikacin nephrotoxicity in patients with chronic liver disease.
Rev. Invest. Clin 42: 93
1990
Contreras AM, Gamba G, Cortés J, Santiago Y, Nares F, Jimenez-Sanchez G, Bobadilla J, Espinosa A, López G, Valadez A, Sifuentes J y Peña JC.
Serial trough and peak amikacin levels in plasma as predictors of nephrotoxicity.
Atimicrob Agents Chemother 33: 973-976
1989
Gamba G, Arizpe D, Ferral H, Contreras AM, Cortés J, Malé R, Mendoza A, Viniegra L y Peña JC.
Amikacin Nephrotoxicity. Incidence, clinical course and risk factors. A prospective study in a teaching hospital.
Rev Invest Clin 40: 135-141
1988
Integrantes de Grupo
Colaboradoras cercanas
| Nombre | Adscipción |
|---|---|
| María Castañeda Bueno | Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán |
| María Chávez-Canales | Instituto de Investigaciones Biomédicas, UNAM |
| Paola de los Heros | Facultad de Medicina, UNAM |
| Adriana Mercado | Instituto Nacional de Cardiología Ignacio Chávez |
| Erika Moreno Martínez | Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán |
| Diana Pacheco-Alvarez | Universidad Panamericana |
Asistente Administrativa
Tel. 55548-70900 ext. 2511
| Nombre | Correo electrónico |
|---|---|
| Rosario Aguirre Leal |  |
Estudiantes de posgrado, pregrado, cursos impartidos y congresos
En mi laboratorio han realizado tesis estudiantes de Doctorado (16), Maestría (6), Especialidad (5) y Licenciatura (12). Han realizado el Posdoctorado (7) y el Servicio Social de la carrera de Medicina (30).
He impartido ininterrumpidamente una vez al año el curso de Fisiología Cardiovascular, Pulmonar y Renal, modulo II de la materia de Fisiología Humana, del currículo del segundo año de la carrera de Medicina en la Facultad de Medicina, UNAM desde 1993 hasta 2022.
Asistimos regularmente al Congreso Anual de la Sociedad Americana de Nefrología en los Estados Unidos desde 1989, al Congreso Anual de la Sociedad Americana de Fisiología en los Estados Unidos, desde 2000 y al Congreso Anual del Instituto Mexicanos de Investigaciones Nefrológicas en México desde 1993. En estos congresos generalmente es donde presentamos nuestros trabajos de investigación.
Distinciones y Reconocimientos
de gran relevancia
| Descripción | Año |
|---|---|
| Carl W. Gottschalk Distinguished Lectureship of the American Physiology Society | 2024 |
| Sistema Nacional de Investigadores, nivel III | 2004-2024 |
| Steve Hebert Lecturer of the American Physiological Society Experimental Biology, meeting, Boston, MA | 2013 |
| Premio Ciudad Capital Heberto Castillo | 2011 |
| Premio Nacional de Ciencias y Artes | 2010 |
| Premio Universidad Nacional | 2008 |
| Distinción Universidad Nacional para Jóvenes Académicos | 2000 |
| Premio Miguel Alemán Valdés | 1999 |